GPI-1046

Modify Date: 2024-04-02 17:13:27

GPI-1046 structure	Common Name	GPI-1046
	CAS Number	186452-09-5	Molecular Weight	360.447
	Density	1.1±0.1 g/cm3	Boiling Point	501.5±60.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₈N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	257.1±32.9 °C

Use of GPI-1046

GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2].

Name	3-pyridin-3-ylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate
Synonym	More Synonyms

Description	GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	GLT1
References	[1]. Sari Y, et al. Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats. Neuroscience. 2012 Dec 27;227:327-35. [2]. Eberling JL, et al. The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys. Exp Neurol. 2002 Dec;178(2):236-42.

Density	1.1±0.1 g/cm3
Boiling Point	501.5±60.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₈N₂O₄
Molecular Weight	360.447
Flash Point	257.1±32.9 °C
Exact Mass	360.204895
PSA	90.40000
LogP	1.54
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.529

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

L-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)-, 3-(3-pyridinyl)propyl ester

GPI

(S)-3-(Pyridin-3-yl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate

3-(3-Pyridinyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)-L-prolinate

gpi-1046

DC Chemicals Limited
China
Product Name: GPI-1046
Price: $2500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (S)-3-(Pyridine-3-yl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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