PD0166285

Modify Date: 2024-01-22 20:38:37

PD0166285 Structure
PD0166285 structure
Common Name PD0166285
CAS Number 185039-89-8 Molecular Weight 512.431
Density 1.3±0.1 g/cm3 Boiling Point 665.3±65.0 °C at 760 mmHg
Molecular Formula C26H27Cl2N5O2 Melting Point N/A
MSDS N/A Flash Point 356.2±34.3 °C

 Use of PD0166285


PD0166285 is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50s of 24 and 72 nM, respectively.

 Names

Name PD166285
Synonym More Synonyms

 PD0166285 Biological Activity

Description PD0166285 is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50s of 24 and 72 nM, respectively.
Related Catalog
Target

IC50: 24 nM (WEE1), 72 nM (Myt1)[1]

In Vitro PD0166285 is a pyridopyrimidine class of molecule. At the cellular level, 0.5 μM PD0166285 dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines. PD0166285 sensitizes radiation-induced cell killing in p53 mutant HT29 cells and in the E6-transfected, p53-null ovarian cancer cell line PA-1 but to a lesser extent in p53 wild-type PA-1 cells. PD0166285 abrogates irradiation-induced G2 arrest and significantly increases mitotic cell populations. Biologically, PD0166285 acts as a radiosensitizer to sensitize cells to radiation-induced cell death with a sensitivity enhancement ratio of 1.23[1].
Cell Assay For PA-1 cell clonogenic assay, growing cells are irradiated with the indicated dose of γ-radiation (2–8 Gy). Cells are subsequently cultured in the original medium for 12 h, followed by treatment of 0.4 μM PD0166285 or DMSO control for another 4 h[1].
References

[1]. Wang Y, et al. Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. Cancer Res. 2001 Nov 15;61(22):8211-7.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 665.3±65.0 °C at 760 mmHg
Molecular Formula C26H27Cl2N5O2
Molecular Weight 512.431
Flash Point 356.2±34.3 °C
Exact Mass 511.154175
LogP 5.09
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.637
Storage condition -20℃
Water Solubility Insuluble (4.9E-4 g/L) (25 ºC)

 Synonyms

PD166285
TCMDC-140940
6-(2,6-Dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-
6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
PD0166285
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: PD0166285
  • Price: $650.0/100mg $1100.0/250mg $2200.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


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PD0166285 suppliers


Price: ¥1691/10 mM * 1 mL in DMSO

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