CM-579

Modify Date: 2024-01-30 19:02:25

CM-579 structure	Common Name	CM-579
	CAS Number	1846570-40-8	Molecular Weight	492.65
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₄₀N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CM-579

CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].

Name	CM-579

Description	CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase Signaling Pathways >> Epigenetics >> DNA Methyltransferase
Target	DNA Methyltransferase:32 nM (IC50) DNMT1:1.5 nM (Kd) DNMT3A:92 nM (IC50) DNMT3B:1000 nM (IC50) G9a:16 nM (IC50)
In Vitro	The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively[1].
References	[1]. San José-Enériz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.

Molecular Formula	C₂₉H₄₀N₄O₃
Molecular Weight	492.65
Storage condition	2-8℃

DC Chemicals Limited
China
Product Name: CM-579
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥2500/5 mg

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CM-579

Use of CM-579

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CM-579 Biological Activity

Chemical & Physical Properties