fluspirilene
fluspirilene structure
|
Common Name | fluspirilene | ||
|---|---|---|---|---|
| CAS Number | 1841-19-6 | Molecular Weight | 475.573 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 668.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C29H31F2N3O | Melting Point | 187.5-190° | |
| MSDS | Chinese USA | Flash Point | 358.3±31.5 °C | |
Use of fluspirileneFluspirilene is a non-competitive antagonist of L-type calcium channels with an IC50 of 0.03 μM. Fluspirileneis a long-acting injectable depot antipsychotic drug used for schizophrenia. |
| Name | Fluspirilene |
|---|---|
| Synonym | More Synonyms |
| Description | Fluspirilene is a non-competitive antagonist of L-type calcium channels with an IC50 of 0.03 μM. Fluspirileneis a long-acting injectable depot antipsychotic drug used for schizophrenia. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.03 μM (L-type calcium channel)[1] |
| In Vitro | Fluspirilene, at concentrations which non-competitively modify dihydropyridine binding, selectively antagonizes the effects of calcium-channel activators[1]. Fluspirilene decreases the viability and suppresses sphere-forming of glioma stem cell lines in a dose-dependent manner. Fluspirilene demonstrates the inhibition of proliferation of T98, U87 and all GSC lines at 1.25, 2.5, and 5 μM, while it inhibits the proliferation of U251 and SNB19 at 2.5 and 5 μM[2]. |
| In Vivo | Mice treated with fluspirilene shows a remarkable reduction of the tumor size. Fluspirilene significantly prolongs survival of the TGS04 mouse model[2]. |
| Cell Assay | To investigate the effect of fluspirilene on cell proliferation, cells are treated with 1.25, 2.5, and 5 μM of fluspirilene. GSC viability is assessed using a Cell Counting Kit-8[2]. |
| Animal Admin | Mice[2] The mice are randomly assigned to two groups and treated with either fluspirilene (n=5) or with DMSO as a control group (n=5). All mice are given intramuscular injections of 200 μL of DMSO or fluspirilene dissolved in DMSO at 1 mg/kg body weight four times[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 668.9±55.0 °C at 760 mmHg |
| Melting Point | 187.5-190° |
| Molecular Formula | C29H31F2N3O |
| Molecular Weight | 475.573 |
| Flash Point | 358.3±31.5 °C |
| Exact Mass | 475.243530 |
| PSA | 35.58000 |
| LogP | 3.89 |
| Appearance of Characters | amorphous solid | white to yellow |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.632 |
| InChIKey | QOYHHIBFXOOADH-UHFFFAOYSA-N |
| SMILES | O=C1NCN(c2ccccc2)C12CCN(CCCC(c1ccc(F)cc1)c1ccc(F)cc1)CC2 |
| Storage condition | room temp |
| Water Solubility | DMSO: soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | UN 3249 |
| WGK Germany | 3 |
| RTECS | XX8750000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2933990090 |
|
~97%
fluspirilene CAS#:1841-19-6 |
| Literature: Schmidt, Andreas; Marchetti, Mauro; Eilbracht, Peter Tetrahedron, 2004 , vol. 60, # 50 p. 11487 - 11492 |
|
~68%
fluspirilene CAS#:1841-19-6 |
| Literature: Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637 |
|
~%
fluspirilene CAS#:1841-19-6 |
| Literature: Tetrahedron, , vol. 60, # 50 p. 11487 - 11492 |
|
~%
fluspirilene CAS#:1841-19-6 |
| Literature: Tetrahedron, , vol. 60, # 50 p. 11487 - 11492 |
|
~%
fluspirilene CAS#:1841-19-6 |
| Literature: Tetrahedron, , vol. 60, # 50 p. 11487 - 11492 |
|
~%
fluspirilene CAS#:1841-19-6 |
| Literature: Tetrahedron, , vol. 57, # 8 p. 1631 - 1637 |
|
~%
fluspirilene CAS#:1841-19-6 |
| Literature: Tetrahedron, , vol. 57, # 8 p. 1631 - 1637 |
|
~%
fluspirilene CAS#:1841-19-6 |
| Literature: Tetrahedron, , vol. 57, # 8 p. 1631 - 1637 |
|
~%
fluspirilene CAS#:1841-19-6 |
| Literature: Tetrahedron, , vol. 57, # 8 p. 1631 - 1637 |
![1,1'-(4-bromobutylidene)bis[4-fluorobenzene] structure](https://image.chemsrc.com/caspic/421/57668-61-8.png)
![1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one structure](https://image.chemsrc.com/caspic/259/1021-25-6.png)
![8-[4,4-bis(p-fluorophenyl)-4-hydroxybutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one structure](https://image.chemsrc.com/caspic/218/817642-33-4.png)
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Proc. Natl. Acad. Sci. U. S. A. 104 , 19023-8, (2007) Autophagy is a lysosome-dependent cellular catabolic mechanism mediating the turnover of intracellular organelles and long-lived proteins. Reduction of autophagy activity has been shown to lead to the... |
|
|
Determination of fluspirilene in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation.
J. Chromatogr. A. 828(1-2) , 219-27, (1998) An ultra-sensitive method for the determination of fluspirilene in plasma was established, using high-performance liquid chromatographic separation with tandem mass spectrometric detection. The sample... |
|
|
Test therapy in the treatment of generalized anxiety disorders with low dose fluspirilene.
Prog. Neuropsychopharmacol. Biol. Psychiatry 19(6) , 1049-60, (1995) 1. The present double-blind study was designed to determine under three different conditions (0.5 mg, 1.0 mg, 1.5 mg per week) whether response or non-response within a two-week test-therapy predicts ... |
| 8-[4,4-Bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
| fluspirilene |
| 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one,R 6218 |
| 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one R 6218 |
| 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl- |
| 1,3,8-Triazaspiro(4.5)decan-4-one, 8-(4,4-bis(4-fluorophenyl)butyl)-1-phenyl- |