SRI31215 2TFA

Modify Date: 2025-09-11 20:15:18

SRI31215 2TFA Structure
SRI31215 2TFA structure
Common Name SRI31215 2TFA
CAS Number 1832686-44-8 Molecular Weight 533.59
Density N/A Boiling Point N/A
Molecular Formula C27H34F3N5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SRI31215 2TFA


SRI 31215 (TFA), a triplex inhibitor of matriptase, hepsin and hepatocyte growth factor activator (HGFA) with IC50s of 0.69 μM, 0.65 μM, 0.3 μM, blocks pro-HGF activation and thus mimics the activity of HAI-1/2[1].

 Names

Name SRI 31215 TFA

 SRI31215 2TFA Biological Activity

Description SRI 31215 (TFA), a triplex inhibitor of matriptase, hepsin and hepatocyte growth factor activator (HGFA) with IC50s of 0.69 μM, 0.65 μM, 0.3 μM, blocks pro-HGF activation and thus mimics the activity of HAI-1/2[1].
Related Catalog
Target

IC50: 0.69 μM (matriptase), 0.65 μM (hepsin), 0.3 μM (HGFA)[1]

References

[1]. Owusu BY, et al. Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling. Oncotarget. 2016 May 17;7(20):29492-506.

 Chemical & Physical Properties

Molecular Formula C27H34F3N5O3
Molecular Weight 533.59
Storage condition 2-8℃
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