1832686-44-8

1832686-44-8 structure

Name: SRI31215 2TFA
Chemical Name: SRI 31215 TFA
CAS Number: 1832686-44-8
Molecular Formula: C₂₇H₃₄F₃N₅O₃
Molecular Weight: 533.59
Catalog: Research Areas Cancer
Create Date: 2019-06-01 12:37:21
Modify Date: 2025-09-11 20:15:18
SRI 31215 (TFA), a triplex inhibitor of matriptase, hepsin and hepatocyte growth factor activator (HGFA) with IC50s of 0.69 μM, 0.65 μM, 0.3 μM, blocks pro-HGF activation and thus mimics the activity of HAI-1/2[1].

Name	SRI 31215 TFA

Description	SRI 31215 (TFA), a triplex inhibitor of matriptase, hepsin and hepatocyte growth factor activator (HGFA) with IC50s of 0.69 μM, 0.65 μM, 0.3 μM, blocks pro-HGF activation and thus mimics the activity of HAI-1/2[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 0.69 μM (matriptase), 0.65 μM (hepsin), 0.3 μM (HGFA)[1]
References	[1]. Owusu BY, et al. Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling. Oncotarget. 2016 May 17;7(20):29492-506.