SRI31215 2TFA

Names

[ Name ]:
SRI31215 2TFA

Biological Activity

[Description]:

SRI 31215 (TFA), a triplex inhibitor of matriptase, hepsin and hepatocyte growth factor activator (HGFA) with IC50s of 0.69 μM, 0.65 μM, 0.3 μM, blocks pro-HGF activation and thus mimics the activity of HAI-1/2[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 0.69 μM (matriptase), 0.65 μM (hepsin), 0.3 μM (HGFA)[1]

[References]

[1]. Owusu BY, et al. Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling. Oncotarget. 2016 May 17;7(20):29492-506.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₄F₃N₅O₃

[ Molecular Weight ]:
533.59

[ Storage condition ]:
2-8℃

Related Compounds

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