Tipiracil hydrochloride

Modify Date: 2024-01-02 18:42:52

Tipiracil hydrochloride Structure
Tipiracil hydrochloride structure
Common Name Tipiracil hydrochloride
CAS Number 183204-72-0 Molecular Weight 279.123
Density N/A Boiling Point N/A
Molecular Formula C9H12Cl2N4O2 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Tipiracil hydrochloride


Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

 Names

Name 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione,hydrochloride
Synonym More Synonyms

 Tipiracil hydrochloride Biological Activity

Description Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
Related Catalog
In Vitro Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells[1]. Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD[2].
References

[1]. Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9.

[2]. Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):993-1001.

 Chemical & Physical Properties

Molecular Formula C9H12Cl2N4O2
Molecular Weight 279.123
Exact Mass 278.033722
PSA 93.33000
LogP 1.95390
Storage condition 2-8°C

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

Tipiracil HCl
5-amino-1-[(5-chloro-2,6-dihydroxypyrimidin-4-yl)methyl]-3,4-dihydro-2H-pyrrolium chloride
2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-, hydrochloride (1:1)
TAS-1-462
Tipiracil hydrochloride
2H-pyrrolium, 5-amino-1-[(5-chloro-2,6-dihydroxy-4-pyrimidinyl)methyl]-3,4-dihydro-, chloride (1:1)
5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride (1:1)
Tipiracil hydrochloride (JAN)
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