Top Suppliers:I want be here




183204-72-0

183204-72-0 structure
183204-72-0 structure

Name 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione,hydrochloride
Synonyms Tipiracil HCl
5-amino-1-[(5-chloro-2,6-dihydroxypyrimidin-4-yl)methyl]-3,4-dihydro-2H-pyrrolium chloride
2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-, hydrochloride (1:1)
TAS-1-462
Tipiracil hydrochloride
2H-pyrrolium, 5-amino-1-[(5-chloro-2,6-dihydroxy-4-pyrimidinyl)methyl]-3,4-dihydro-, chloride (1:1)
5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride (1:1)
Tipiracil hydrochloride (JAN)
Description Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
Related Catalog
In Vitro Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells[1]. Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD[2].
References

[1]. Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9.

[2]. Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):993-1001.

Molecular Formula C9H12Cl2N4O2
Molecular Weight 279.123
Exact Mass 278.033722
PSA 93.33000
LogP 1.95390
Storage condition 2-8°C
RIDADR NONH for all modes of transport
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.