NH2-methylpropanamide-Exatecan TFA

Modify Date: 2024-01-09 18:08:03

NH2-methylpropanamide-Exatecan TFA Structure
NH2-methylpropanamide-Exatecan TFA structure
Common Name NH2-methylpropanamide-Exatecan TFA
CAS Number 1817857-35-4 Molecular Weight 634.58
Density N/A Boiling Point N/A
Molecular Formula C30H30F4N4O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NH2-methylpropanamide-Exatecan TFA


NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan (HY-13631), which is the common ADC Cytotoxin used in the synthesis of ADC. Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].

 Names

Name NH2-methylpropanamide-Exatecan TFA

 NH2-methylpropanamide-Exatecan TFA Biological Activity

Description NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan (HY-13631), which is the common ADC Cytotoxin used in the synthesis of ADC. Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].
Related Catalog
Target

Topoisomerase I[1]

References

[1]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.  

 Chemical & Physical Properties

Molecular Formula C30H30F4N4O7
Molecular Weight 634.58
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