1817857-35-4

1817857-35-4 structure

Name: NH2-methylpropanamide-Exatecan TFA
Chemical Name: NH2-methylpropanamide-Exatecan TFA
CAS Number: 1817857-35-4
Molecular Formula: C₃₀H₃₀F₄N₄O₇
Molecular Weight: 634.58
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2023-12-07 15:06:39
Modify Date: 2024-01-09 18:08:03
NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan (HY-13631), which is the common ADC Cytotoxin used in the synthesis of ADC. Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].

Name	NH2-methylpropanamide-Exatecan TFA

Description	NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan (HY-13631), which is the common ADC Cytotoxin used in the synthesis of ADC. Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
Target	Topoisomerase I[1]
References	[1]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.

Molecular Formula	C₃₀H₃₀F₄N₄O₇
Molecular Weight	634.58