IRAK4-IN-16

Modify Date: 2025-09-07 10:07:58

IRAK4-IN-16 structure	Common Name	IRAK4-IN-16
	CAS Number	1812188-83-2	Molecular Weight	390.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₂₀F₂N₈O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IRAK4-IN-16

IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC50 of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC50 values of 0.2, 0.2, 0.6, and 2.7 μM, respectively[1].

Name	IRAK4-IN-16

Description	IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC50 of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC50 values of 0.2, 0.2, 0.6, and 2.7 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4:2.5 ± 0.8 nM (IC50)
References	[1]. Chen Y, et al. Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma. Eur J Med Chem. 2020 Mar 15;190:112092.

Molecular Formula	C₁₇H₂₀F₂N₈O
Molecular Weight	390.39

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IRAK4-IN-16

Use of IRAK4-IN-16

Names

IRAK4-IN-16 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.