IRAK4-IN-15
Modify Date: 2025-09-04 16:34:29
IRAK4-IN-15 structure
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Common Name | IRAK4-IN-15 | ||
|---|---|---|---|---|
| CAS Number | 2667681-85-6 | Molecular Weight | 488.56 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H29FN10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IRAK4-IN-15IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 µM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1]. |
| Name | IRAK4-IN-15 |
|---|
| Description | IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 µM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1]. |
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| Related Catalog | |
| Target |
IRAK4:0.002 μM (IC50) |
| In Vitro | IRAK4-IN-15 (compound 35) shows cell pIRAK4 potencies with an IC50 of 0.21 µM[1]. IRAK4-IN-15 (compound 35) shows selectivity with IC50s of 0.002,1.2, >10,1.5, 0.23, 0.48, 0.93, 0.57 µM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively[1]. |
| References |
| Molecular Formula | C25H29FN10 |
|---|---|
| Molecular Weight | 488.56 |