Hainantoxin-III

Modify Date: 2024-01-09 10:22:43

Hainantoxin-III Structure
Hainantoxin-III structure
Common Name Hainantoxin-III
CAS Number 1809149-40-3 Molecular Weight 3608.12
Density N/A Boiling Point N/A
Molecular Formula C154H228N44O45S6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Hainantoxin-III


Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC50 value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 and 30.2 nM, respectively[1].

 Names

Name Hainantoxin-III

 Hainantoxin-III Biological Activity

Description Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC50 value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 and 30.2 nM, respectively[1].
Related Catalog
Target

Nav1.2

Nav1.3

Nav1.7

References

[1]. Yucheng Xiao, et al. Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by twospider toxins: hainantoxin-III and hainantoxin-IV. Eur J Pharmacol. 2003 Sep 5;477(1):1-7.  

[2]. Yunxiao Zhang, et al. Engineering of highly potent and selective HNTX-III mutant against hNav1.7 sodium channel for treatment of pain. J Biol Chem. 2021 Jan-Jun:296:100326.  

 Chemical & Physical Properties

Molecular Formula C154H228N44O45S6
Molecular Weight 3608.12
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