1809149-40-3

1809149-40-3 structure

Name: Hainantoxin-III
Chemical Name: Hainantoxin-III
CAS Number: 1809149-40-3
Molecular Formula: C₁₅₄H₂₂₈N₄₄O₄₅S₆
Molecular Weight: 3608.12
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2024-01-09 10:22:43
Modify Date: 2025-10-29 14:03:06
Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC50 value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 and 30.2 nM, respectively[1].

Name	Hainantoxin-III

Description	Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC50 value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 and 30.2 nM, respectively[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	Nav1.2 Nav1.3 Nav1.7
References	[1]. Yucheng Xiao, et al. Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by twospider toxins: hainantoxin-III and hainantoxin-IV. Eur J Pharmacol. 2003 Sep 5;477(1):1-7. [2]. Yunxiao Zhang, et al. Engineering of highly potent and selective HNTX-III mutant against hNav1.7 sodium channel for treatment of pain. J Biol Chem. 2021 Jan-Jun:296:100326.

Molecular Formula	C₁₅₄H₂₂₈N₄₄O₄₅S₆
Molecular Weight	3608.12