YNT-185
Modify Date: 2024-01-14 17:54:40
YNT-185 structure
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Common Name | YNT-185 | ||
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| CAS Number | 1804978-81-1 | Molecular Weight | 615.74 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H37N5O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of YNT-185YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2]. |
| Name | YNT-185 |
|---|
| Description | YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2]. |
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| Related Catalog | |
| In Vivo | YNT-185 (20-40 mg/kg; i.p.) increases wakefulness in mice[2]. YNT-185 (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice[2]. Animal Model: Male wild-type C57BL/6J mice[2] Dosage: 20, 40 mg/kg Administration: I.p. Result: Wake time was also significantly increased. |
| References |
| Molecular Formula | C33H37N5O5S |
|---|---|
| Molecular Weight | 615.74 |
| Storage condition | -20°C |