S-22153

Modify Date: 2024-01-03 17:48:16

S-22153 structure	Common Name	S-22153
	CAS Number	180304-07-8	Molecular Weight	247.35600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₇NOS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of S-22153

S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2].

Name	N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide

Description	S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor Research Areas >> Neurological Disease
Target	MT1:19 nM (EC50) MT2:4.6 nM (EC50)
In Vivo	S-22153 sets the temperature and activity periods to approximately 24 hr and increase the circadian amplitude of both rhythms in mice, which exposed to continuous light[1] . Animal Model: 7 weeks old Male B6D2F1 mice, which exposed to continuous light for 10-18 days[1] Dosage: 20 mg/kg Administration: Daily intraperitoneal (i.p.) for 19 days Result: Set the temperature and activity periods to approximately 24 hr and increased the circadian amplitude of both rhythms in mice, which exposed to continuous light.
References	[1]. Li XM, et al. Circadian rhythm entrainment with melatonin, melatonin receptor antagonist S22153 or their combination in mice exposed to constant light. J Pineal Res. 2004;37(3):176-184. [2]. Audinot V, et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003;367(6):553-561.

Molecular Formula	C₁₄H₁₇NOS
Molecular Weight	247.35600
Exact Mass	247.10300
PSA	60.83000
LogP	3.98260

DC Chemicals Limited
China
Product Name: S-22153
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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