Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) ammonium acetate salt

Modify Date: 2024-04-07 10:35:50

Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) ammonium acetate salt structure	Common Name	Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) ammonium acetate salt
	CAS Number	1802078-31-4	Molecular Weight	1533.50
	Density	1.4±0.1 g/cm3	Boiling Point	1881.2±65.0 °C at 760 mmHg
	Molecular Formula	C₆₈H₈₈N₁₄O₂₇	Melting Point	N/A
	MSDS	N/A	Flash Point	1091.5±34.3 °C

Use of Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) ammonium acetate salt

Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.

Name	Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) ammonium acetate salt
Synonym	More Synonyms

Description	Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Others
References	[1]. Vila-Real H, et al. Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease. J Med Chem. 2015 Jul 23;58(14):5408-18. [2]. Yen YC, et al. Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors. Biochemistry. 2019 Nov 5;58(44):4424-4435.

Description

Related Catalog

Signaling Pathways >> Neuronal Signaling >> Beta-secretase

Research Areas >> Others

References

[1]. Vila-Real H, et al. Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease. J Med Chem. 2015 Jul 23;58(14):5408-18.

[2]. Yen YC, et al. Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors. Biochemistry. 2019 Nov 5;58(44):4424-4435.

Density	1.4±0.1 g/cm3
Boiling Point	1881.2±65.0 °C at 760 mmHg
Molecular Formula	C₆₈H₈₈N₁₄O₂₇
Molecular Weight	1533.50
Flash Point	1091.5±34.3 °C
Exact Mass	1532.594360
LogP	3.47
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.600

L-Lysine, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-

N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine

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Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) ammonium acetate salt

Use of Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) ammonium acetate salt

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