GNF-6702
Modify Date: 2025-09-18 03:40:40
GNF-6702 structure
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Common Name | GNF-6702 | ||
|---|---|---|---|---|
| CAS Number | 1799329-72-8 | Molecular Weight | 429.406 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C22H16FN7O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNF-6702GNF-6702 (GNF6702) is a selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM; displays no inhibitory effect on caspase-like and the trypsin-like activities (>10 uM); does not inhibit the mammalian proteasome or growth of mammalian cells, and is well-tolerated in mice; clears parasites in mouse models of kinetoplastid infections. |
| Name | GNF6702 |
|---|---|
| Synonym | More Synonyms |
| Description | GNF-6702 (GNF6702) is a selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM; displays no inhibitory effect on caspase-like and the trypsin-like activities (>10 uM); does not inhibit the mammalian proteasome or growth of mammalian cells, and is well-tolerated in mice; clears parasites in mouse models of kinetoplastid infections. |
|---|---|
| References | References 1. Khare S, et al. Nature. 2016 Sep 8;537(7619):229-233. View Related Products by Target Parasite |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H16FN7O3 |
| Molecular Weight | 429.406 |
| Exact Mass | 429.134949 |
| LogP | 0.88 |
| Index of Refraction | 1.733 |
| InChIKey | WXZFCGRYVWYYTG-UHFFFAOYSA-N |
| SMILES | Cc1nc(C)c(C(=O)Nc2ccc(F)c(-c3nc4ncc(-c5ccccn5)cn4n3)c2)o1 |
| N-{4-Fluoro-3-[6-(2-pyridinyl)[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl}-2,4-dimethyl-1,3-oxazole-5-carboxamide |
| 5-Oxazolecarboxamide, N-[4-fluoro-3-[6-(2-pyridinyl)[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl- |
| GNF6702 |
| MFCD31612571 |