1799329-72-8

1799329-72-8 structure

Name: GNF-6702
Chemical Name: GNF6702
CAS Number: 1799329-72-8
Molecular Formula: C₂₂H₁₆FN₇O₃
Molecular Weight: 429.406
Catalog: Research Areas Infection
Create Date: 2020-01-12 08:47:50
Modify Date: 2025-09-18 03:40:40
GNF-6702 (GNF6702) is a selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM; displays no inhibitory effect on caspase-like and the trypsin-like activities (>10 uM); does not inhibit the mammalian proteasome or growth of mammalian cells, and is well-tolerated in mice; clears parasites in mouse models of kinetoplastid infections.

Name	GNF6702
Synonyms	N-{4-Fluoro-3-[6-(2-pyridinyl)[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl}-2,4-dimethyl-1,3-oxazole-5-carboxamide 5-Oxazolecarboxamide, N-[4-fluoro-3-[6-(2-pyridinyl)[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl- GNF6702 MFCD31612571

Description	GNF-6702 (GNF6702) is a selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM; displays no inhibitory effect on caspase-like and the trypsin-like activities (>10 uM); does not inhibit the mammalian proteasome or growth of mammalian cells, and is well-tolerated in mice; clears parasites in mouse models of kinetoplastid infections.
References	References 1. Khare S, et al. Nature. 2016 Sep 8;537(7619):229-233. View Related Products by Target Parasite