VX-150

Modify Date: 2024-01-05 18:38:56

VX-150 Structure
VX-150 structure
Common Name VX-150
CAS Number 1793080-72-4 Molecular Weight 516.34
Density 1.59±0.1 g/cm3 Boiling Point N/A
Molecular Formula C21H17F4N2O7P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VX-150


VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1].

 Names

Name VX-150
Synonym More Synonyms

 VX-150 Biological Activity

Description VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1].
Related Catalog
Target

Nav1.8

In Vitro VX-150 is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold)[1].
References

[1]. Hemme J Hijma, et al. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22(8):1814-1826.

 Chemical & Physical Properties

Density 1.59±0.1 g/cm3
Molecular Formula C21H17F4N2O7P
Molecular Weight 516.34
Storage condition -20°C

 Synonyms

(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate
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