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VX-150

Names

[ CAS No. ]:
1793080-72-4

[ Name ]:
VX-150

[Synonym ]:
(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate

Biological Activity

[Description]:

VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Neurological Disease

[Target]

Nav1.8


[In Vitro]

VX-150 is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold)[1].

[References]

[1]. Hemme J Hijma, et al. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22(8):1814-1826.

Chemical & Physical Properties

[ Density]:
1.59±0.1 g/cm3

[ Molecular Formula ]:
C21H17F4N2O7P

[ Molecular Weight ]:
516.34

[ Storage condition ]:
-20°C

Related Compounds