LDN 209929 2HCl
Modify Date: 2024-02-24 22:55:09
LDN 209929 2HCl structure
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Common Name | LDN 209929 2HCl | ||
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| CAS Number | 1784281-97-5 | Molecular Weight | 405.77 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H19Cl3N2OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LDN 209929 2HClLDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50=55 nM) with180-fold selectivity verses DYRK2 (IC50=9.9 μM). LDN-209929 is a optimized analogue of LDN-192960 (HY-13455)[2]. |
| Name | LDN-209929 dihydrochloride |
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| Description | LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50=55 nM) with180-fold selectivity verses DYRK2 (IC50=9.9 μM). LDN-209929 is a optimized analogue of LDN-192960 (HY-13455)[2]. |
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| Related Catalog | |
| Target |
IC50: 55 nM (haspin kinase) IC50: 9.9 μM (DYRK2)[1] |
| In Vitro | Haspin: Haploid Germ Cell-Specific Nuclear Protein Kinase, is a serine/threonine kinase expressed in a variety of tissues (e.g., testis, bone marrow, thymus, and spleen). Haspin also plays an important role in mitosis, where it phosphorylates histone H3 at Thr-3 (H3T3) in G2/early prophase, becomes maximal during prometaphase/metaphase and then diminishes during anaphase[1]. DYRKs belong to the CMGC family of ePKs and can be further divided into class 1 kinases DYRK1A and 1B, and class 2 kinases DYRK2, 3, and 4. The activity of DYRKs depends upon autophosphorylation of an essential activation loop tyrosine during synthesis[1]. |
| References |
| Molecular Formula | C17H19Cl3N2OS |
|---|---|
| Molecular Weight | 405.77 |
| Storage condition | 2-8°C |