TOS-ARG-OME.HCL
TOS-ARG-OME.HCL structure
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Common Name | TOS-ARG-OME.HCL | ||
|---|---|---|---|---|
| CAS Number | 1784-03-8 | Molecular Weight | 378.875 | |
| Density | N/A | Boiling Point | 544.1ºC at 760mmHg | |
| Molecular Formula | C14H23ClN4O4S | Melting Point | 145-147(lit.) | |
| MSDS | USA | Flash Point | 282.9ºC | |
Use of TOS-ARG-OME.HCLTAME hydrochloride is an inhibitor of anaphase-promoting complex (APC), which prevents its activation by Cdc20 and Cdh1. |
| Name | methyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | TAME hydrochloride is an inhibitor of anaphase-promoting complex (APC), which prevents its activation by Cdc20 and Cdh1. |
|---|---|
| Related Catalog | |
| Target |
APC [1]. |
| In Vitro | TAME shows inhibitory effect on APC activation when added to mitotic Xenopus extract. TAME (1-200 μM) inhibits Cdc20 association with mitotic APC and also inhibits Cdh1 association with interphase APC. TAME significantly inhibits crosslinking of the IR peptide to Cdc27 and Cdc16 but only slightly reduces crosslinking to Cdc23 and Apc7 at 20 µM; TAME strongly inhibits crosslinking to all APC subunits at 200 µM. TAME also inhibits binding of wild type Cdc20 to the APC, but not binding of a ΔIR mutant[1]. TAME (200 μM) induces Cdc20 dissociation from the APC in mitotic Xenopus extract calls for APC-dependent ubiquitination. TAME induces Cdc20 dissociation from the APC by promoting Cdc20 ubiquitination, but the dissociation can be suppresses by Cyclin B1. TAME terminates cyclin B1 ubiquitination prematurely[2]. TAME interacts with ATP by β and γ phosphate and the adenine ring of ATP. TAME in combination with the Mg(II) ion accelerates the ATP hydrolysis process[3]. |
| References |
| Boiling Point | 544.1ºC at 760mmHg |
|---|---|
| Melting Point | 145-147(lit.) |
| Molecular Formula | C14H23ClN4O4S |
| Molecular Weight | 378.875 |
| Flash Point | 282.9ºC |
| Exact Mass | 378.112854 |
| PSA | 142.75000 |
| LogP | 3.54280 |
| Vapour Pressure | 6.73E-12mmHg at 25°C |
| Index of Refraction | -14 ° (C=4, H2O) |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2935009090 |
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TOS-ARG-OME.HCL CAS#:1784-03-8 |
| Literature: Journal of Biological Chemistry, , vol. 127, p. 643,647 |
|
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TOS-ARG-OME.HCL CAS#:1784-03-8 |
| Literature: Journal of Biological Chemistry, , vol. 127, p. 643,647 |
|
~%
TOS-ARG-OME.HCL CAS#:1784-03-8 |
| Literature: Journal of Biological Chemistry, , vol. 127, p. 643,647 |
CAS#:14279-64-2| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Vinyl functionalized silica hybrid monolith-based trypsin microreactor for on line digestion and separation via thiol-ene "click" strategy.
J. Chromatogr. A. 1218 , 7982-7988, (2011) A novel thiol-ene "click" strategy for the preparation of monolithic trypsin microreactor was proposed. The hybrid organic-inorganic monolithic capillary column with ene-functionality was fabricated b... |
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Rabbit plasminogen and plasmin isozymes.
Meth. Enzymol. 45 , 273, (1976)
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A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.
Can. J. Biochem. Physiol. 37 , 1393, (1959)
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| Nalpha-4-Tosyl-L-arginine methyl ester hydrochloride |
| Na-p-Tosyl-L-arginine methyl ester hydrochloride |
| (S)-Methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate hydrochloride |
| Nα-p-Toluenesulfonyl-L-arginine Methyl Ester Hydrochloride |
| N-4-Tosyl-L-arginine methyl ester hydrochloride |
| Tos-Arg-OMe.HCl |
| Tos-Arg-Ome·Hcl |
| EINECS 217-235-1 |
| TAME hydrochloride |
| Imino{[(4S)-5-methoxy-4-{[(4-methylphenyl)sulfonyl]amino}-5-oxopentyl]amino}methanaminium chloride |
| MFCD00012578 |
| L-Ornithine, N-(diaminomethylene)-N-[(4-methylphenyl)sulfonyl]-, methyl ester, hydrochloride (1:1) |
| Nα-p-Tosyl-L-arginine methyl ester hydrochloride |
| Methyl N2-((p-tolyl)sulphonyl)-L-argininate monohydrochloride |
| Nalpha-Tosyl-L-arginine Methyl Ester Hydrochloride |
| TOS-ARG-OME HCL |
| Methyl N-(diaminomethylene)-N-[(4-methylphenyl)sulfonyl]-L-ornithinate hydrochloride (1:1) |
| Nα-Tosyl-L-arginine Methyl Ester Hydrochloride |
| Nalpha-p-Toluenesulfonyl-L-Arginine Methyl Ester Hydrochloride |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: TOS-ARG-OME.HCL
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- GL Biochem (Shanghai) Ltd.
- China
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
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- DC Chemicals Limited
- China
- Product Name: TAME hydrochloride
- Price: $100.0/100mg $200.0/250mg $400.0/1g
- Purity: 98.0%
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- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: TAME hydrochloride
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
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- Nanjing Peptide Biotech Ltd
- China
- Product Name: Tos-Arg-OMe.HCl
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Delivery: 7 Day
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: N-4-Tosyl-L-arginine methyl ester hydrochloride
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
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- Email: enquiry@dycnchem.com
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