7-Methylguanine-d3

Modify Date: 2024-04-01 18:45:35

7-Methylguanine-d3 Structure
7-Methylguanine-d3 structure
Common Name 7-Methylguanine-d3
CAS Number 17829-03-7 Molecular Weight 168.17
Density N/A Boiling Point N/A
Molecular Formula C6H4D3N5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 7-Methylguanine-d3


7-Methylguanine-d3 is the deuterium labeled 7-Methylguanine[1]. 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method[2].

 Names

Name 7-Methylguanine-d3

 7-Methylguanine-d3 Biological Activity

Description 7-Methylguanine-d3 is the deuterium labeled 7-Methylguanine[1]. 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130(35):11570-1.  

 Chemical & Physical Properties

Molecular Formula C6H4D3N5O
Molecular Weight 168.17