432545-62-5

432545-62-5 structure

Name: 7-Hydroxymethotrexate-d3
Chemical Name: N-(4-{[(2,4-Diamino-7-oxo-1,7-dihydro-6-pteridinyl)methyl][(2H3)methyl]amino}benzoyl)glutamic acid
CAS Number: 432545-62-5
Molecular Formula: C₂₀H₁₉D₃N₈O₆
Molecular Weight: 473.45700
Catalog: Research Areas Metabolic Disease
Create Date: 2017-04-15 14:19:40
Modify Date: 2024-01-14 22:26:32
7-Hydroxymethotrexate-d3 is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].

Name	N-(4-{[(2,4-Diamino-7-oxo-1,7-dihydro-6-pteridinyl)methyl][(2H3)methyl]amino}benzoyl)glutamic acid
Synonyms	7-Hydroxy Methotrexate-d3

Description	7-Hydroxymethotrexate-d3 is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].
References	[1]. L Fahrig, et al. Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX. Cancer Chemother Pharmacol. 1989;23(3):156-60. [2]. Ping Guo, et al. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2007 Apr 11;43(5):1789-95. [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.