CMI977

Modify Date: 2024-01-13 21:11:54

CMI977 Structure
CMI977 structure
Common Name CMI977
CAS Number 175212-04-1 Molecular Weight 322.33
Density 1.2±0.1 g/cm3 Boiling Point 233.6±23.0 °C at 760 mmHg
Molecular Formula C16H19FN2O4 Melting Point N/A
MSDS N/A Flash Point 95.0±22.6 °C

 Use of CMI977


CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.

 Names

Name CMI977
Synonym More Synonyms

 CMI977 Biological Activity

Description CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.
Related Catalog
In Vitro CMI977 is a potent 5-lipoxygenase (5-LO) inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. It is a single enantiomer with an all-trans (2S,5S) configuration. Of the four isomers of CMI977, the S,S isomer is found to have the best biological activity and is selected for further development.
References

[1]. Xiong Cai, et al. Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor. Org. Proc. Res. Dev., 1999, 3 (1), pp 73-76.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 233.6±23.0 °C at 760 mmHg
Molecular Formula C16H19FN2O4
Molecular Weight 322.33
Flash Point 95.0±22.6 °C
LogP 0.52
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.499
Storage condition 2-8℃

 Synonyms

Urea, N-hydroxy-N-propyl-
Q5WMS52P89
VNR0T3Q498
1-Hydroxy-1-propylurea