Oxaprozin, potassium salt
Modify Date: 2025-08-26 11:24:35
Oxaprozin, potassium salt structure
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Common Name | Oxaprozin, potassium salt | ||
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| CAS Number | 174064-08-5 | Molecular Weight | 331.40700 | |
| Density | N/A | Boiling Point | 467ºC at 760mmHg | |
| Molecular Formula | C18H14KNO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 236.2ºC | |
Use of Oxaprozin, potassium saltOxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2]. |
| Name | potassium,3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoate |
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| Synonym | More Synonyms |
| Description | Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2]. |
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| Related Catalog | |
| Target |
COX-1:2.2 μM (IC50) COX-2:36 μM (IC50) NF-κB Akt pAKT IKK |
| In Vitro | Oxaprozin (0-100 μM) induces apoptosis in a dose-dependent manner. Oxaprozin increases caspase-3 activity in the activated but not in the resting condition. NF-κB activation is inhibited by Oxaprozin (50 μM). Oxaprozin inhibits activation of the IKK system induced by the reagent IκBα[1]. Oxaprozin (100 μM) induces the strongest proapoptotic effect and significantly increases CD40L-treated monocyte apoptosis. Oxaprozin treatment inhibits CD40L-induced Akt and NF-κB (p65) phosphorylation[2]. |
| References |
| Boiling Point | 467ºC at 760mmHg |
|---|---|
| Molecular Formula | C18H14KNO3 |
| Molecular Weight | 331.40700 |
| Flash Point | 236.2ºC |
| Exact Mass | 331.06100 |
| PSA | 66.16000 |
| LogP | 2.69110 |
| Vapour Pressure | 1.6E-09mmHg at 25°C |
| oxaprozin potassium salt |
| potassium 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoate |
| Daypro Alta |
| ML56O2Z92I |
| UNII-ML56O2Z92I |
| 2-Oxazolepropanoic acid,4,5-diphenyl-,potassium salt |
| OXAPROZIN POTASSIUM |
| 4,5-diphenyl-2-oxazolepropionic acid potassium salt |