Imperatoxin A

Modify Date: 2024-01-30 20:18:32

Imperatoxin A structure	Common Name	Imperatoxin A
	CAS Number	172451-37-5	Molecular Weight	3764.4
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄₈H₂₆₀N₅₈O₄₅S₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Imperatoxin A

Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca2+-release channels/ryanodine receptors (RyRs)? enhances the influx of Ca2+ from the sarcoplasmatic reticulum into the cell[1].

Name	IMPERATOXIN A

Description	Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca2+-release channels/ryanodine receptors (RyRs)? enhances the influx of Ca2+ from the sarcoplasmatic reticulum into the cell[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Target	RyRs[1]
References	[1]. Georgina B Gurrola, et al. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca2+-Release Channels/Ryanodine Receptors. Pharmaceuticals (Basel). 2010 Apr 1;3(4):1093-1107.

Molecular Formula	C₁₄₈H₂₆₀N₅₈O₄₅S₆
Molecular Weight	3764.4
Appearance of Characters	lyophilized powder
Storage condition	−20°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	7-9-36/37
RIDADR	NONH for all modes of transport
WGK Germany	3

Scorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscle.

Proc. Natl. Acad. Sci. U. S. A. 89 , 12185-12189, (1992)

We report the purification of two peptides, called "imperatoxin inhibitor" and "imperatoxin activator," from the venom of the scorpion Pandinus imperator targeted against ryanodine receptor Ca(2+)-rel...

Peptide probe of ryanodine receptor function. Imperatoxin A, a peptide from the venom of the scorpion Pandinus imperator, selectively activates skeletal-type ryanodine receptor isoforms.

J. Biol. Chem. 270 , 28696-28704, (1995)

We have used [3H]ryanodine binding experiments and single channel recordings to provide convergent descriptions of the effect of imperatoxin A (IpTxa), a approximately 5-kDa peptide from the venom of ...

Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors.

FEBS Lett. 405 , 385-389, (1997)

We present the complete amino acid sequence of Imperatoxin A (IpTx(a)), a 33-amino-acid peptide from the venom of the scorpion P. imperator which activates Ca2+ release channels/ryanodine receptors (R...

Imperatoxin A

Use of Imperatoxin A

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Imperatoxin A Biological Activity

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