Efaproxiral sodium

Modify Date: 2024-01-02 12:13:52

Efaproxiral sodium Structure
Efaproxiral sodium structure
Common Name Efaproxiral sodium
CAS Number 170787-99-2 Molecular Weight 363.383
Density N/A Boiling Point 554.5ºC at 760mmHg
Molecular Formula C20H22NNaO4 Melting Point N/A
MSDS N/A Flash Point 289.2ºC

 Use of Efaproxiral sodium


Efaproxiral sodium is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.

 Names

Name sodium,2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoate
Synonym More Synonyms

 Efaproxiral sodium Biological Activity

Description Efaproxiral sodium is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.
Related Catalog
References

[1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784.

 Chemical & Physical Properties

Boiling Point 554.5ºC at 760mmHg
Molecular Formula C20H22NNaO4
Molecular Weight 363.383
Flash Point 289.2ºC
Exact Mass 363.144653
PSA 78.46000
LogP 2.46490
Vapour Pressure 3.93E-13mmHg at 25°C
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi
HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Efaproxiral sodium
Revaproxyn
RSR-13
Sodium 2-(4-{2-[(3,5-dimethylphenyl)amino]-2-oxoethyl}phenoxy)-2-methylpropanoate
RSR 13 sodium
Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-, sodium salt (1:1)
Efaproxiral (sodium)
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