Chloridazon

Modify Date: 2024-01-04 10:30:41

Chloridazon Structure
Chloridazon structure
Common Name Chloridazon
CAS Number 1698-60-8 Molecular Weight 221.643
Density 1.4±0.1 g/cm3 Boiling Point 312.2±52.0 °C at 760 mmHg
Molecular Formula C10H8ClN3O Melting Point 206ºC (tech., 198-202ºC)
MSDS Chinese USA Flash Point 142.6±30.7 °C
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning

 Names

Name chloridazon
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 312.2±52.0 °C at 760 mmHg
Melting Point 206ºC (tech., 198-202ºC)
Molecular Formula C10H8ClN3O
Molecular Weight 221.643
Flash Point 142.6±30.7 °C
Exact Mass 221.035583
PSA 60.91000
LogP 0.73
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.668

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UR6125000
CHEMICAL NAME :
3(2H)-Pyridazinone, 5-amino-4-chloro-2-phenyl-
CAS REGISTRY NUMBER :
1698-60-8
BEILSTEIN REFERENCE NO. :
0397241
LAST UPDATED :
199706
DATA ITEMS CITED :
26
MOLECULAR FORMULA :
C10-H8-Cl-N3-O
MOLECULAR WEIGHT :
221.66
WISWESSER LINE NOTATION :
T6NNVJ BR& DG EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
647 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>30800 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
194 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
598 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
235 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1205 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle contraction or spasticity
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
493 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
162 gm/kg/2Y-C
TOXIC EFFECTS :
Musculoskeletal - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 gm/kg/30D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6006 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in thyroid weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/m3/4H/17W-I
TOXIC EFFECTS :
Liver - other changes Blood - changes in other cell count (unspecified) Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
142 gm/kg/92W-C
TOXIC EFFECTS :
Liver - changes in liver weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
10 mg/m3/4H/17W-I
TOXIC EFFECTS :
Liver - other changes Blood - changes in other cell count (unspecified) Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1 mg/m3/4H
SEX/DURATION :
male 72 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
175 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
50 mg/m3
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(1),80,1985 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H317-H410
Precautionary Statements P273-P280-P501
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi: Irritant;N: Dangerous for the environment;
Risk Phrases R43;R50/53
Safety Phrases S24-S37-S60-S61
RIDADR 3077
RTECS UR6125000
HS Code 2933990017

 Synthetic Route

~63%

Chloridazon Structure

Chloridazon

CAS#:1698-60-8

Literature: Collection of Czechoslovak Chemical Communications, , vol. 50, # 2 p. 492 - 502

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Chloridazon Structure

Chloridazon

CAS#:1698-60-8

Literature: US4454318 A1, ;

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Chloridazon Structure

Chloridazon

CAS#:1698-60-8

Literature: US4454318 A1, ;

~%

Chloridazon Structure

Chloridazon

CAS#:1698-60-8

Literature: US4454318 A1, ;

 Customs

HS Code 2933990017
Summary 2933990017 6,7-dihydrodipyrido[1,2-a:2',1'-c]pyrazine-5,8-diium bromide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

 Articles26

More Articles
Destruction of halogen-containing pesticides by means of detonation combustion.

Environ. Sci. Pollut. Res. Int. 20(2) , 855-61, (2013)

Pesticides that contain a halogen functional group have been destructed by means of detonative combustion. The following compounds were examined: (1) atrazine-2-chloro-4-ethylamino-6-isopropylamino-1,...

Prevention of chloridazon and metribuzin pollution using lignin-based formulations

Environ. Pollut. 158(5) , 1412-9, (2010)

The herbicides chloridazon and metribuzin, identified as groundwater pollutants, were incorporated in lignin-based granules with different sizes to obtain controlled release formulations (CRFs) and re...

Time- and dose-dependent induction of HSP70 in Lemna minor exposed to different environmental stressors.

Bull. Environ. Contam. Toxicol. 87(3) , 226-30, (2011)

The objective of this study was to examine the influence of different stressors, including cadmium (heavy metal), anthracene (polycyclic aromatic hydrocarbon-PAH) and chloridazon (herbicide), on popul...

 Synonyms

5-Amino-4-chlor-2-phenylpyridazin-3(2H)-on
Chloridazon
pyrazon
3(2H)-Pyridazinone, 5-amino-4-chloro-2-phenyl-
MFCD00055402
PYRAMIN
5-amino-4-chloro-2-phenylpyridazin-3(2H)-one
5-Amino-4-chloro-2-phenyl-2H-pyridazin-3-one
PAC
EINECS 216-920-2
5-Amino-4-chloro-2-phenyl-3(2H)-pyridazinone
Chloridazon,Pyrazone
Poly (acrylic acid-co-hypophosphite) sodium salt
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