Apcin-A

Modify Date: 2025-08-26 14:17:06

Apcin-A Structure
Apcin-A structure
Common Name Apcin-A
CAS Number 1683617-62-0 Molecular Weight 342.61
Density N/A Boiling Point N/A
Molecular Formula C10H14Cl3N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Apcin-A


Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V (HY-130257)[1].

 Names

Name Apcin-A

 Apcin-A Biological Activity

Description Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V (HY-130257)[1].
Related Catalog
References

[1]. Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2.

 Chemical & Physical Properties

Molecular Formula C10H14Cl3N5O2
Molecular Weight 342.61
InChIKey JQTSJVDIFMKETH-UHFFFAOYSA-N
SMILES NCCCOC(=O)NC(Nc1ncccn1)C(Cl)(Cl)Cl

 Safety Information

Hazard Codes Xi
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