MMV008138

Modify Date: 2025-08-25 19:42:42

MMV008138 structure	Common Name	MMV008138
	CAS Number	1679333-73-3	Molecular Weight	361.22
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₄Cl₂N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MMV008138

MMV008138 is a species-selective antimalarial agent which targets the enzyme 2- C-methyl-d-erythritol 4-phosphate cytidylyltransferase (IspD) in the MEP pathway, with an IC50 of 250 nM for P. falciparum Dd2 strain[1][2].

Name	MMV008138

Description	MMV008138 is a species-selective antimalarial agent which targets the enzyme 2- C-methyl-d-erythritol 4-phosphate cytidylyltransferase (IspD) in the MEP pathway, with an IC50 of 250 nM for P. falciparum Dd2 strain[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
Target	IC50: 250 nM (P. falciparum Dd2 strain)[1]
References	[1]. Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4(4):549-559. [2]. Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9.

Molecular Formula	C₁₈H₁₄Cl₂N₂O₂
Molecular Weight	361.22
Storage condition	-20°C

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MMV008138

Use of MMV008138

Names

MMV008138 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.