1679333-73-3

1679333-73-3 structure

Name: MMV008138
Chemical Name: MMV008138
CAS Number: 1679333-73-3
Molecular Formula: C₁₈H₁₄Cl₂N₂O₂
Molecular Weight: 361.22
Catalog: Signaling Pathways Anti-infection Parasite
Create Date: 2019-09-09 11:28:50
Modify Date: 2024-01-04 08:51:26
MMV008138 is a species-selective antimalarial agent which targets the enzyme 2- C-methyl-d-erythritol 4-phosphate cytidylyltransferase (IspD) in the MEP pathway, with an IC50 of 250 nM for P. falciparum Dd2 strain[1][2].

Name	MMV008138

Description	MMV008138 is a species-selective antimalarial agent which targets the enzyme 2- C-methyl-d-erythritol 4-phosphate cytidylyltransferase (IspD) in the MEP pathway, with an IC50 of 250 nM for P. falciparum Dd2 strain[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
Target	IC50: 250 nM (P. falciparum Dd2 strain)[1]
References	[1]. Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4(4):549-559. [2]. Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9.