MMV008138

Names

[ Name ]:
MMV008138

Biological Activity

[Description]:

MMV008138 is a species-selective antimalarial agent which targets the enzyme 2- C-methyl-d-erythritol 4-phosphate cytidylyltransferase (IspD) in the MEP pathway, with an IC50 of 250 nM for P. falciparum Dd2 strain[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[Target]

IC50: 250 nM (P. falciparum Dd2 strain)[1]

[References]

[1]. Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4(4):549-559.

[2]. Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₄Cl₂N₂O₂

[ Molecular Weight ]:
361.22

[ Storage condition ]:
-20°C

Related Compounds

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