Gne-0946

Modify Date: 2025-09-21 18:11:19

Gne-0946 Structure
Gne-0946 structure
Common Name Gne-0946
CAS Number 1677667-24-1 Molecular Weight 460.79
Density N/A Boiling Point N/A
Molecular Formula C22H12ClF3N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Gne-0946


GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.

 Names

Name GNE-0946

 Gne-0946 Biological Activity

Description GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.
Related Catalog
References

[1]. Fauber BP, et al. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12.

 Chemical & Physical Properties

Molecular Formula C22H12ClF3N2O4
Molecular Weight 460.79
InChIKey UAAUZNSONHHQQI-UHFFFAOYSA-N
SMILES O=C(O)c1ccc(-c2nc(C(=O)c3c(Cl)cccc3C(F)(F)F)n3ccccc23)cc1O
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