TGP-377/421
Modify Date: 2025-09-23 12:01:29
TGP-377/421 structure
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Common Name | TGP-377/421 | ||
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| CAS Number | 16752-89-9 | Molecular Weight | 340.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H16N6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TGP-377/421TGP-377/421 (Targapre-miR-377/421) is a smalll molecule targets pre-miR-377 and inhibits its processing, binds to miR-377's Dicer processing site with Kd of 29 uM.TGP-377/421 inhibits the cellular biogenesis of miR-377 in HUVECs, reduced mature miR-377 levels in a dose-dependent fashion with IC50 of 5 uM, also inhibits miR-421. |
| Name | TGP-377/421 |
|---|
| Description | TGP-377/421 (Targapre-miR-377/421) is a smalll molecule targets pre-miR-377 and inhibits its processing, binds to miR-377's Dicer processing site with Kd of 29 uM.TGP-377/421 inhibits the cellular biogenesis of miR-377 in HUVECs, reduced mature miR-377 levels in a dose-dependent fashion with IC50 of 5 uM, also inhibits miR-421. |
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| References | 1. Hafeez S Haniff, et al. Nat Chem. 2020 Oct;12(10):952-961. |
| Molecular Formula | C20H16N6 |
|---|---|
| Molecular Weight | 340.39 |
| InChIKey | AQEJANNNADGRSY-UHFFFAOYSA-N |
| SMILES | Nc1ccc2nc(-c3cccc(-c4nc5ccc(N)cc5[nH]4)c3)[nH]c2c1 |