TGP-377/421
Names
[ CAS No. ]:
16752-89-9
[ Name ]:
TGP-377/421
Biological Activity
[Description]:
TGP-377/421 (Targapre-miR-377/421) is a smalll molecule targets pre-miR-377 and inhibits its processing, binds to miR-377's Dicer processing site with Kd of 29 uM.TGP-377/421 inhibits the cellular biogenesis of miR-377 in HUVECs, reduced mature miR-377 levels in a dose-dependent fashion with IC50 of 5 uM, also inhibits miR-421.
[References]
1. Hafeez S Haniff, et al. Nat Chem. 2020 Oct;12(10):952-961.
Chemical & Physical Properties
[ Molecular Formula ]:
C20H16N6
[ Molecular Weight ]:
340.39