MS-377
Names
[ CAS No. ]:
206862-30-8
[ Name ]:
MS-377
Biological Activity
[Description]:
MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities; markedly increases dopamine and serotonin release in the medial prefrontal cortex, significantly attenuates the effect of PCP in rat brain. Schizophrenia Discontinued
[References]
References 1. Takahashi S, et al. Psychopharmacology (Berl). 1999 Aug;145(3):295-302. 2. Karasawa J, et al. Eur J Pharmacol. 2000 Jul 14;400(1):51-7. 3. Yamada S, et al. Eur J Pharmacol. 2000 Aug 25;402(3):251-4. 4. Takahashi S, et al. Eur J Pharmacol. 2001 Sep 21;427(3):211-9. View Related Products by Target Sigma Receptor Schizophrenia
Chemical & Physical Properties
[ Molecular Formula ]:
C18H26ClN3O2
[ Molecular Weight ]:
351.875
Related Compounds
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.