MS 15203

Names

[ Name ]:
MS 15203

[Synonym ]:
MFCD00434754

Biological Activity

[Description]:

MS15203 is a potent and selective GPR171 agonist. MS15203 increases food intake and body weight. MS15203 increases neuronal activity. MS15203 significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

MS15203 (MS0015203) dose-dependently increases [[35]S]GTPγS binding and inhibits adenylyl cyclase activity in rat hypothalamic membranes[1].

[In Vivo]

MS15203 (MS0015203) (3 mg/kg; i.p.) causes an increase in neuronal activity within cells containing GPR171 in the PVN[1]. .MS15203 (3 mg/kg; i.p.) significantly increases food intake at 4 and 8 hours[1]. MS15203 (3 mg/kg; i.p.) significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP[1].

[References]

[1]. Wardman JH, et al. Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Sci Signal. 2016 May 31;9(430):ra55.

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Boiling Point ]:
561.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₁NO₅

[ Molecular Weight ]:
249.21900

[ Flash Point ]:
293.2ºC

[ Exact Mass ]:
249.06400

[ PSA ]:
103.70000

[ LogP ]:
1.67060

[ Index of Refraction ]:
1.639

Safety Information

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%