NTE-122

Modify Date: 2024-02-09 17:09:03

NTE-122 Structure
NTE-122 structure
 Common Name NTE-122
CAS Number 166967-84-6 Molecular Weight 703.828
Density N/A Boiling Point N/A
Molecular Formula C38H60Cl2N6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NTE-122


NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with the IC50 in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis[1].

 Names

Name 1,1'-[trans-1,4-Cyclohexanediylbis(methylene)]bis{1-cyclohexyl-3-[4-(dimethylamino)phenyl]urea} dihydrochloride
Synonym More Synonyms

 NTE-122 Biological Activity

Description NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with the IC50 in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis[1].
Related Catalog
References

[1]. Y Azuma, et al. NTE-122, an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, Prevents the Progression of Atherogenesis in Cholesterol-Fed Rabbits. Jpn J Pharmacol. 2001 May;86(1):120-3.  

 Chemical & Physical Properties

Molecular Formula C38H60Cl2N6O2
Molecular Weight 703.828
Exact Mass 702.415466

 Synonyms

1,1'-[trans-1,4-Cyclohexanediylbis(methylene)]bis{1-cyclohexyl-3-[4-(dimethylamino)phenyl]urea} dihydrochloride
Urea, N,N''-[trans-1,4-cyclohexanediylbis(methylene)]bis[N-cyclohexyl-N'-[4-(dimethylamino)phenyl]-, hydrochloride (1:2)
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Chemsrc provides NTE-122(CAS#:166967-84-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of NTE-122 are included as well.>> amp version: NTE-122

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