NTE-122

Names

[ Name ]:
NTE-122

[Synonym ]:
1,1'-[trans-1,4-Cyclohexanediylbis(methylene)]bis{1-cyclohexyl-3-[4-(dimethylamino)phenyl]urea} dihydrochloride
Urea, N,N''-[trans-1,4-cyclohexanediylbis(methylene)]bis[N-cyclohexyl-N'-[4-(dimethylamino)phenyl]-, hydrochloride (1:2)

Biological Activity

[Description]:

NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with the IC50 in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[References]

[1]. Y Azuma, et al. NTE-122, an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, Prevents the Progression of Atherogenesis in Cholesterol-Fed Rabbits. Jpn J Pharmacol. 2001 May;86(1):120-3.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₈H₆₀Cl₂N₆O₂

[ Molecular Weight ]:
703.828

[ Exact Mass ]:
702.415466

Related Compounds

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