166967-84-6

166967-84-6 structure

Name: NTE-122
Chemical Name: 1,1'-[trans-1,4-Cyclohexanediylbis(methylene)]bis{1-cyclohexyl-3-[4-(dimethylamino)phenyl]urea} dihydrochloride
CAS Number: 166967-84-6
Molecular Formula: C₃₈H₆₀Cl₂N₆O₂
Molecular Weight: 703.828
Catalog: Research Areas Cardiovascular Disease
Create Date: 2021-01-09 16:58:24
Modify Date: 2025-09-13 09:04:54
NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with the IC50 in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis[1].

Name	1,1'-[trans-1,4-Cyclohexanediylbis(methylene)]bis{1-cyclohexyl-3-[4-(dimethylamino)phenyl]urea} dihydrochloride
Synonyms	1,1'-[trans-1,4-Cyclohexanediylbis(methylene)]bis{1-cyclohexyl-3-[4-(dimethylamino)phenyl]urea} dihydrochloride Urea, N,N''-[trans-1,4-cyclohexanediylbis(methylene)]bis[N-cyclohexyl-N'-[4-(dimethylamino)phenyl]-, hydrochloride (1:2)

Description	NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with the IC50 in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis[1].
Related Catalog	Research Areas >> Cardiovascular Disease
References	[1]. Y Azuma, et al. NTE-122, an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, Prevents the Progression of Atherogenesis in Cholesterol-Fed Rabbits. Jpn J Pharmacol. 2001 May;86(1):120-3.