Tyrosinase (206-214) (human) acetate salt

Modify Date: 2025-09-23 21:08:35

Tyrosinase (206-214) (human) acetate salt structure	Common Name	Tyrosinase (206-214) (human) acetate salt
	CAS Number	166188-11-0	Molecular Weight	1186.406
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₆₁H₈₃N₁₅O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tyrosinase (206-214) (human) acetate salt

Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL)[1].

Name	L-Alanyl-L-phenylalanyl-L-leucyl-L-prolyl-L-tryptophyl-L-histidyl-N5-(diaminomethylene)-L-ornithyl-L-leucyl-L-phenylalanine
Synonym	More Synonyms

Description	Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL)[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase
In Vitro	Tyrosinase (206-214), human (AFLPWHRLF) can be used to generate melanoma-specific T cells for adoptive immunotherapy, as well as in peptide vaccines for HLA-A24+ melanoma[1].
In Vivo	Tyrosinase (206-214) is administered intranasally (i.n.; 45 µL; weekly for three weeks) into HLA-A24 transgenic (A24Tg) mice. Tyrosinase (206-214) shows an accumulation of murine CD3+ and CD8+ cells around the bronchioles. All A24Tg immunized with Tyrosinase (206-214) died after lethal A/HK483 infection[2].
References	[1]. X Kang, et al. Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes. J Immunol. 1995 Aug 1;155(3):1343-8. [2]. Toru Ichihashi, et al. Cross-protective peptide vaccine against influenza A viruses developed in HLA-A*2402 human immunity model. PLoS One. 2011;6(9):e24626.

Density	1.4±0.1 g/cm3
Molecular Formula	C₆₁H₈₃N₁₅O₁₀
Molecular Weight	1186.406
Exact Mass	1185.644775
LogP	5.31
Index of Refraction	1.665

L-Phenylalanine, L-alanyl-L-phenylalanyl-L-leucyl-L-prolyl-L-tryptophyl-L-histidyl-N5-(diaminomethylene)-L-ornithyl-L-leucyl-

L-Alanyl-L-phenylalanyl-L-leucyl-L-prolyl-L-tryptophyl-L-histidyl-N5-(diaminomethylene)-L-ornithyl-L-leucyl-L-phenylalanine

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Tyrosinase (206-214) (human) acetate salt

Use of Tyrosinase (206-214) (human) acetate salt

Names

Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.