DKM 3-42
Modify Date: 2024-01-04 11:24:01
DKM 3-42 structure
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Common Name | DKM 3-42 | ||
|---|---|---|---|---|
| CAS Number | 164925-73-9 | Molecular Weight | 207.317 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H21NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DKM 3-42DKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity; impairs A549 serum-survival in a dose-responsive manner, significantly attenuates tumor growth in vivo in A549 tumor xenografts in mice with dose of DKM 3-42 (50mg/kg ip) once per day. |
| Name | DKM 3-42 |
|---|
| Description | DKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity; impairs A549 serum-survival in a dose-responsive manner, significantly attenuates tumor growth in vivo in A549 tumor xenografts in mice with dose of DKM 3-42 (50mg/kg ip) once per day. |
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| References | References 1. Counihan JL, et al. ACS Chem Biol. 2018 Jul 13. doi: 10.1021/acschembio.8b00381. View Related Products by Target Aldehyde Dehydrogenase (ALDH) |
| Molecular Formula | C13H21NO |
|---|---|
| Molecular Weight | 207.317 |