164925-73-9
164925-73-9 structure
- Name: DKM 3-42
- Chemical Name: DKM 3-42
- CAS Number: 164925-73-9
- Molecular Formula: C13H21NO
- Molecular Weight: 207.317
- Create Date: 2020-01-11 16:54:52
- Modify Date: 2024-01-04 11:24:01
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DKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity; impairs A549 serum-survival in a dose-responsive manner, significantly attenuates tumor growth in vivo in A549 tumor xenografts in mice with dose of DKM 3-42 (50mg/kg ip) once per day.
| Name | DKM 3-42 |
|---|
| Description | DKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity; impairs A549 serum-survival in a dose-responsive manner, significantly attenuates tumor growth in vivo in A549 tumor xenografts in mice with dose of DKM 3-42 (50mg/kg ip) once per day. |
|---|---|
| References | References 1. Counihan JL, et al. ACS Chem Biol. 2018 Jul 13. doi: 10.1021/acschembio.8b00381. View Related Products by Target Aldehyde Dehydrogenase (ALDH) |
| Molecular Formula | C13H21NO |
|---|---|
| Molecular Weight | 207.317 |