(Rac)-AMG8379

Modify Date: 2024-02-03 12:17:49

(Rac)-AMG8379 structure	Common Name	(Rac)-AMG8379
	CAS Number	1641574-26-6	Molecular Weight	543.93
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₁₆ClF₂N₃O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (Rac)-AMG8379

(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively [1].

Name	(Rac)-AMG8379

Description	(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively [1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
References	[1]. Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160.

Molecular Formula	C₂₅H₁₆ClF₂N₃O₅S
Molecular Weight	543.93

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(Rac)-AMG8379 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.