1641574-26-6

1641574-26-6 structure

Name: (Rac)-AMG8379
Chemical Name: (Rac)-AMG8379
CAS Number: 1641574-26-6
Molecular Formula: C₂₅H₁₆ClF₂N₃O₅S
Molecular Weight: 543.93
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2020-06-01 20:21:54
Modify Date: 2024-02-03 12:17:49
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively [1].

Name	(Rac)-AMG8379

Description	(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively [1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
References	[1]. Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160.

Molecular Formula	C₂₅H₁₆ClF₂N₃O₅S
Molecular Weight	543.93