TH588 hydrochloride
Modify Date: 2024-01-14 13:51:13
TH588 hydrochloride structure
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Common Name | TH588 hydrochloride | ||
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| CAS Number | 1640282-30-9 | Molecular Weight | 331.628 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H13Cl3N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TH588 hydrochlorideTH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells.IC50 value: 5 nM [1]Target: MTH1 inhibitorTH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts. |
| Name | TH588 hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells.IC50 value: 5 nM [1]Target: MTH1 inhibitorTH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts. |
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| Related Catalog | |
| References |
| Molecular Formula | C13H13Cl3N4 |
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| Molecular Weight | 331.628 |
| Exact Mass | 330.020569 |
| Storage condition | 2-8℃ |
| 2,4-Pyrimidinediamine, N4-cyclopropyl-6-(2,3-dichlorophenyl)-, hydrochloride (1:1) |
| N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine hydrochloride (1:1) |
| TH588 (hydrochloride) |