1640282-30-9

1640282-30-9 structure

Name: TH588 hydrochloride
Chemical Name: TH588 hydrochloride
CAS Number: 1640282-30-9
Molecular Formula: C₁₃H₁₃Cl₃N₄
Molecular Weight: 331.628
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2018-06-19 08:03:08
Modify Date: 2024-01-14 13:51:13
TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells.IC50 value: 5 nM [1]Target: MTH1 inhibitorTH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts.

Name	TH588 hydrochloride
Synonyms	2,4-Pyrimidinediamine, N4-cyclopropyl-6-(2,3-dichlorophenyl)-, hydrochloride (1:1) N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine hydrochloride (1:1) TH588 (hydrochloride)

Description	TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells.IC50 value: 5 nM [1]Target: MTH1 inhibitorTH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Cancer
References	[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.